Letrozole Mode of Action

Letrozole is an oral medication commonly used in the treatment of certain types of breast cancer, particularly in postmenopausal women. Understanding its mode of action is crucial for both patients and healthcare providers.

Mechanism of Action

The letrozole mode of action primarily involves the inhibition of aromatase, an enzyme responsible for converting androgens into estrogens. By decreasing estrogen levels in the body, letrozole effectively fights hormone-receptor-positive breast cancer.

Key Processes Involved

• Aromatase Inhibition: Letrozole blocks the aromatase enzyme, reducing the production of estrogen.
• Decrease in Estrogen Levels: Lower estrogen levels lead to https://letrozolebodybuilding.com/product/letrozol-stada-2-5mg-filmtabletten/ reduced stimulation of estrogen receptors on cancer cells.
• Inhibition of Tumor Growth: Without sufficient estrogen, hormone-sensitive tumors may shrink or grow more slowly.

Clinical Applications

Letrozole is primarily prescribed for:

1. Adjuvant Therapy: Used after surgery to reduce the chance of cancer recurrence.
2. Advanced Breast Cancer: Treating cases where cancer has spread beyond the breast.
3. Infertility Treatment: Sometimes used off-label to stimulate ovulation in women with polycystic ovarian syndrome (PCOS).

Benefits of Letrozole

Using letrozole offers several advantages:

• Improved Survival Rates: Studies indicate that it can lead to better outcomes in breast cancer survival.
• Less Side Effects: Generally considered to have a more favorable side effect profile compared to other hormonal therapies, like tamoxifen.
• Convenient Administration: Administered orally once daily, which enhances patient compliance.

FAQs

What are the common side effects of letrozole?

Common side effects may include:

• Hot flashes
• Joint pain
• Bone thinning (osteoporosis)
• Nausea

How long is letrozole typically prescribed?

Duration of therapy can vary based on individual circumstances, but it is commonly prescribed for 5 years in early-stage breast cancer treatment.

Can letrozole be used during pregnancy?

No, letrozole is contraindicated during pregnancy as it may harm the fetus.

Conclusion

Understanding the letrozole mode of action helps in appreciating its role in breast cancer management. As a potent aromatase inhibitor, it plays a significant part in reducing estrogen levels, thereby inhibiting the growth of hormone-responsive tumors. Patients considering this treatment should discuss potential benefits and side effects with their healthcare providers for informed decision-making.